Extended Data Fig. 3: Continued Synthetic applications in the late-stage functionalization and the preparation of complex molecules. | Nature

Extended Data Fig. 3: Continued Synthetic applications in the late-stage functionalization and the preparation of complex molecules.

From: Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines

Extended Data Fig. 3: Continued Synthetic applications in the late-stage functionalization and the preparation of complex molecules.

a, Modular construction of hybrid chiral amine-containing drug molecules. b, Synthesis of chiral unnatural α-amino carboxamides via late-stage C(sp3)–H functionalization of bioactive carboxylic acid molecules. c, Reduction of 115 to amine 188. d, Conversion of carboxamide 141 to alcohol 188. aRacemic alkyl chloride (1.0 equiv.). bYield of α-chloro amide.

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