Fig. 1: Myelin damage in patients with AD. | Nature

Fig. 1: Myelin damage in patients with AD.

From: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Fig. 1: Myelin damage in patients with AD.The alternative text for this image may have been generated using AI.

Fluorescent immunolabelling of CNP and PLP (myelinated fibres) and IBA1 (microglia) and Me-04 staining (Aβ plaques) in the medial temporal lobe of patients with AD and in unaffected individuals (non-AD). a, Annotated overview image of the medial temporal lobe of a patient with AD indicating the location of magnified images. b, Magnified images of the upper cortical layers in the transentorhinal cortex in patients with AD and in unaffected individuals (n = 3 per group). CA, cornu ammonis; Coll sul: collateral sulcus; DG, dentate gyrus; EC, entorhinal cortex; Fi, fimbria; FusGy, fusiform gyrus; PHg, parahippocampal gyrus; PRC, perirhinal cortex; Sub, subiculum.

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