Extended Data Table 2 Similar to Extended Data Table 1, LinearDesign-generated coding-regions for the VZV gE protein form less base pairs with the UTRs

From: Algorithm for optimized mRNA design improves stability and immunogenicity

  1. Here we used 5 different UTRs: StemiRNA VZV UTRs used in wet lab experiments, BNT-162b2 (BioNTech) UTRs, mRNA-1273 (Moderna) UTRs, CV2CoV (CureVac) UTRs, and human β-globin mRNA UTRs. The 7 coding sequences are gE A–E, gE-Ther and gE-WT, which are used in the wet lab experiments of VZV. The folding free energies and structures are predicted by Vienna RNAfold (-d0 mode); MFEs of CDS are calculated without stop codon.
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