Extended Data Fig. 6: Experimental validation related to EpiSen and PDAC-classical MPs.
From: Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours
(a) Example of EpiSen in HNSCC (SPRR1B+) with the senescence-associated secretory-like phenotype (SLPI+) (representative image from 3 independent experiments). (b) The PDAC-classical MP (panCK+TFF1+) is also observed in other cancer types such as invasive mucinous lung adenocarcinoma (also shown in Fig. 3e). In both PDAC and invasive mucinous lung adenocarcinoma, subsets of cancer cells expressing TFF1 are spatially zonated (representative images from 4 independent experiments per cancer type).
