Extended Data Fig. 10: Coupling and decoupling of MHC-II and Interferon response.
From: Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours
In malignant cells, MHC-II and interferon response are often co-expressed, unlike in non-malignant cells where they are uncoupled (e.g. asterisks in a, right panel in d). Cancer cells co-expressing MHC-II and interferon response frequently form an expression gradient in which the cancer cells co-express both markers on a continuum (upper panels in a and b; panel c; left panel in d). T cells often cluster around cancer cells with high expression of interferon response and MHC class II (left lower panels in a; left lower panel in b; left and middle lower panels in d) (representative images from 3 independent experiments per cancer type).
