Extended Data Fig. 5: Conservation analysis of FNI mAbs key contact residues on the NA of IAVs and IBVs. | Nature

Extended Data Fig. 5: Conservation analysis of FNI mAbs key contact residues on the NA of IAVs and IBVs.

From: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Extended Data Fig. 5: Conservation analysis of FNI mAbs key contact residues on the NA of IAVs and IBVs.

Mean conservation percentage (2009–2022) of key NA contacting residues (R118, D151, E227, R292, and R371) per year (red line). The number of sequences analysed per year is shown (black bars). Sequences retrieved for H1N1, H3N2 and IBV isolates are of human origin, while those for H5N1, H7N9, H5N8 and H5N6 viruses are of both human and animal origin. Sequences were retrieved from GISAID database. IAV sequences conservation was measured against A/New York/392/2004 reference strain. IBV sequences conservation was measured against B/Yamagata/16/88 reference strain.

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