Extended Data Fig. 3: NAI activity of FNI and 1G01 mAbs against pseudoparticles bearing NAs from avian and mammalian influenza A viruses.
From: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
a, Inhibition of sialidase activity of FNI and 1G01 mAbs versus NA-based pseudoparticles bearing N1 from highly pathogenic H5N1 A/Mink/Spain/3691-8_22VIR10586-10/2022 (clade 2.3.4.4) as measure by MUNANA assay. b, Inhibition of neuraminidase enzymatic activity, as measured by ELLA, exerted by anti-NA mAbs against NA-based pseudoparticles bearing N3, N4, or N5 representative of enzootic low pathogenic avian influenza A viruses. c, Inhibition of sialidase activity of FNI and 1G01 mAbs versus NA-only based pseudoparticles bearing NA representative of enzootic swine or canine influenza A viruses as measured by MUNANA assay. Data from n = 1 biologically independent experiment out of two are shown.
