Fig. 2: Structures of mechanoregulatory complexes from the C. reinhardtii axoneme.
From: Axonemal structures reveal mechanoregulatory and disease mechanisms
a, Atomic model depicting the multipartite tethering of IDAf by the MIA complex (FAP73/100), a FAP57 homodimer and T/TH. Coiled coils of CCDC39/40 and FAP189 interact with T/TH and MIA, respectively. b, A conceptual schematic, in the style of a London Underground map, showing the interconnectivity between axonemal complexes in a 96-nm repeat. Circles represent axonemal complexes, coloured lines represent the path of docking factors and alternating grey zones represent protofilaments. DP, distal protrusion. c, Composite cryo-EM map and model of the N-DRC. CaM, calmodulin. d, The position of DRC3 at a fork in the N-DRC structure. e, DRC2, DRC4 and DRC11 position flexible, lysine-rich regions towards the neighbouring DMT. Individual letters indicate amino acids.
