Fig. 3: Transfer hydrogenation substrate scope.
From: Photocatalytic phosphine-mediated water activation for radical hydrogenation
a, The reduction of unactivated alkenes. b, The reduction of styrene derivatives. Yields given correspond to isolated yields. See Supplementary Information for specific reduction conditions that deviate from the standard conditions. Diastereoselectivity was determined by 1H NMR spectroscopy. aTriaryl phosphine P1 as the mediator in combination with 0.2 equivalent of HAT1. bTriaryl phosphine P3 as the mediator in combination with 0.15 equivalent of HAT1. cYield obtained for gram-scale experiment (10.0 mmol scale). dGC yield with tetradecane as internal standard. eReaction conducted at 40 °C. fYield for gram-scale experiment (5.0 mmol scale). Bpin, boronic acid pinacol ester; d.r., diastereomeric ratio; Ts, tosyl.
