Extended Data Fig. 6: CaV1.2 pore domain superposition for EMC-bound and CaVα2δ-bound CaV1.2(ΔC)/CaVβ3. | Nature

Extended Data Fig. 6: CaV1.2 pore domain superposition for EMC-bound and CaVα2δ-bound CaV1.2(ΔC)/CaVβ3.

From: EMC chaperone–CaV structure reveals an ion channel assembly intermediate

Extended Data Fig. 6

Pore domains from the EMC-bound complex are: PD I (yellow orange), PD II (firebrick), PD III (lime), and PD IV (marine). Pore domains from CaV1.2(ΔC)/CaVβ3/CaVα2δ-1 are slate. Calcium ions are from CaV1.2(ΔC)/CaVβ3/CaVα2δ-1. Selectivity filter (SF), hydrophobic cavity, and inner gate regions and select residues are indicated.

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