Extended Data Fig. 4: CaV1.2 structural details.
From: EMC chaperone–CaV structure reveals an ion channel assembly intermediate
a–d, Structures of the indicated VSDs from the CaV1.2(ΔC)/CaVβ3/CaVα2δ-1 complex. Gating charge residues, anionic counter charges (An1 and An2) and aromatic site of the charge transfer centre43,45,55 are shown. e, LigPLOT92 diagram of the CaVα2δ-1 leucine binding site showing hydrogen bonds and ionic interactions (dashed lines) and van der Waals contacts ≤ 5Å. f, LigPLOT92 diagram of blocking lipid: CaV1.2 showing van der Waals contacts ≤ 5Å. Domain I (yellow orange), Domain II (dark red), and Domain III (green) residues are indicated.
