Extended Data Fig. 10: CD8 T cells with a cytotoxic gene expression profile infiltrate healthy and diseased skin in patients with cutaneous lichenoid IRAEs.
From: PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens
A) UMAP projection of CD3e-expressing skin cells from the dataset shown in Extended Data Fig. 9. B) UMAP projection of CD3e-expressing skin cells in A color-coded by Cluster. C) Dot plot of genes defining individual Clusters in B. D) Frequencies of the T cell populations identified in B in lesional vs. non-lesional skin. E-H) Dot plot of genes characterizing activation, cytotoxicity, exhaustion and interferon-response signatures50 in T cell Clusters from B,C. I) Frequency of cells with and without associated TRAV/TRBV sequences from Clusters 1–5 defined in B,C. J) Number and size of all T cell clones from Clusters 2–5 sequenced in lesional and non-lesional skin.
