Fig. 1: Characteristics of zebrafish and mouse tra repertoires.
From: Origin and evolutionary malleability of T cell receptor α diversity
a, CDR3 nucleotide length distributions for cDNAs of wild-type animals. b, CDR3 nucleotide length distributions for cDNAs of animals mutant for trac (zebrafish) or Trac (mouse) genes. For a and b, green bars are in-frame rearrangements and grey bars are out-of-frame rearrangements. c, Analysis of CDR3 regions of wild-type animals. The origins of nucleotide residues are indicated; variable genes (blue), joining genes (red), ambiguous (either from V or J regions) (black) and non-templated (grey). The height of lines is proportional to the cDNA count. Danio rerio, CDR3 sequences combined from six animals; Mus musculus, sequences from three animals. d, Diversity at individual nucleotide positions for 42 nucleotide-long CDR3 sequences. Indicated are germline-dependent contributions to mutual information between nucleotide and gene (V gene, blue bars; J gene, red bars) and germline-independent contributions (conditional entropy when V or J genes are known, grey bars). e, Representation of individual tra and trb cDNA molecules in 1 to 6 D. rerio individuals.
