Extended Data Fig. 9: Coordinated actions of LH-Nts GABA release and VTA-DA Ntsr1 in behavioral reinforcement.
From: Circuit coordination of opposing neuropeptide and neurotransmitter signals
(a) Representative behavioral tracks during RTPP. (b) Average percent time in the light-paired chamber during 10 min pretest, and the first and last 10 min of RTPP (*P < 0.05; control N = 8, sgVgat N = 10, sgNtsr1 N = 9, sgVgat + sgNtsr1 N = 10; purple asterisk sgVgat + sgNtsr1 vs. control). (c–f) Average active and inactive lever presses for the four groups of mice during acquisition. (g–j) Average active and inactive lever presses for the four groups of mice during frequency response analysis (c–j: control N = 9, sgVgat N = 10, sgNtsr1 N = 8, sgVgat + sgNtsr1 N = 10, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). Data are presented as mean ± S.E.M.
