Extended Data Fig. 6: Molecular dating of the F313V NP substitution on the classical swine H1N1 lineage.

a, Tip-dated maximum likelihood phylogeny of all classical H1N1 lineage NP sequences annotated by position 313 residue (left) and isolation host (mirrored tree, right). b, Zoomed in snippet of the part of the ML phylogeny shown in A where the F313V change has occurred. Tip shapes are coloured by 313 residue, estimated dates for key nodes are annotated, and strain names are shown on the right of the tips. c, Zoomed in snippet of the part of the BEAST maximum clade credibility phylogeny where the F313V change has occurred. Tip shapes are coloured by 313 residue, median node age and 95% highest posterior density confidence intervals are annotated for key nodes, posterior probability values are shown for each node, and strain names are shown on the right of the tips. The branch where F313V is believed to have taken place on is annotated in colour (pink and green). Phylogenies were visualised using FigTree.