Extended Data Fig. 7: Ileal TCRβ⁺ IEL profiling of mice with cell type-specific abolition of HNF4α in gut epithelial cells or CD4⁺ T cells.

(a–d) Frequencies of ileal CD4⁺ in the TCRβ⁺ IEL population (a), CD8αα⁺ in the TCRβ⁺CD4⁺CD8β⁻ IEL population (b), CD8αβ⁺ in the TCRβ⁺ IEL population (c), or CD8αα⁺ in the TCRβ⁺CD4⁻CD8β⁻ IEL population (d) from Hnf4α^flox/floxVil1^Cre mice and their littermate controls. (e–h) Frequencies of ileal CD4⁺ in the TCRβ⁺ IEL population (e), ThPOK⁺ in the TCRβ⁺CD4⁺CD8β⁻ IEL population (f), CD8αβ⁺ in the TCRβ⁺ IEL population (g), or CD8αα⁺ in the TCRβ⁺CD4⁻CD8β⁻ IEL population (h) from Hnf4α^flox/floxCD4^Cre mice and their littermate controls. Data are pooled from two independent experiments. n represents biologically independent animals. Bars indicate mean ± SEM values. Statistical analysis was performed using a two-tailed Student’s t-test in d.

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