Extended Data Fig. 7: EVT distribution.
From: A spatially resolved timeline of the human maternal–fetal interface
a. Two hypotheses for intravascular EVT invasion. (Left) Intravasation: orange arrows indicate movements of EVTs from the cell column of the anchoring villi into the decidua and through the wall of the artery into the lumen. (Right) Extravasation: red arrows indicate movement of EVTs from the fetal villi through the intervillous space into the artery. b. Anatomical locations of EVT populations in the decidua. c. Distribution of artery δs, based on the presence of perivascular and/or intravascular EVTs. [Violins left to right] min = 1, max = 2.65, center = 1.7; min = 1.19, max = 3, center = 1.84; min = 1.77, max = 5, center = 3.2; min = 1.6, max = 4.5, center = 2.4. d. Scatter plot of log2(Intravascular/Perivascular) ratio by δ, for arteries with both perivascular and intravascular EVTs present. Black line, fitted linear regression. Regression p-value on top. e. Percentage of arteries with ≤ a given SMA loss (s) threshold, by perivascular or intravascular EVTs present. Arteries were considered to have perivascular or intravascular EVT if the number of EVT in the appropriate compartment was ≥ 5. f. Percentage of arteries with scores ≤ a given endothelial loss (e) threshold, by perivascular or intravascular EVTs present. Arteries were considered to have perivascular or intravascular EVT if the number of EVT in the appropriate artery compartment was ≥ 5.
