Extended Data Fig. 8: Treg co-transplantation suppresses inflammatory cell infiltration and C4-mDAP immunogenicity in a xenogeneic model of PD.
From: Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
a–e, Fischer 344 rats were killed two weeks after intra-striatal co-transplantation of C4-mDAPs with or without Treg cells and CsA. The levels of CD11b+/CD11c+ (a), NKp46+ (b), CD19+ (c), and CD4+/CD8+ (d,d′) cells were assessed through immunofluorescence staining. d′, Most of the yellow dots seen in the +Treg cells, +CsA, and +Treg cells + CsA groups in d are nonspecific signals, not real cells (yellow arrows). e, Expression of HLA class I/II was examined through immunofluorescence staining. (n = 5 per group).
