Extended Data Fig. 11: In vivo effects of Treg co-transplantation with C4-mDAPs.
From: Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
a–d, NSG mice were killed 20 weeks after intra-striatal co-transplantation of C4-mDAPs with or without autologous C4-Treg cells (20,000 cells per mouse). a,b, Representative images (a) and quantitative assessment (b) of hSYP+ within the DL STR. (Two-tailed unpaired t-test; n = 5 per group). c,d, Representative images (c) and quantitative assessment (d) of graft-derived TH+ fibre density in the (i) cingulate cortex (CTX), (ii) perirhinal CTX, (iii) DL STR, and (iv) ventrolateral (VL) STR. T, transplant. (Two-tailed unpaired t-test; n = 3 per group). In box plots in b, the centre line represents the median, box edges represent the interquartile range, and error bars represent maximum and minimum values. Each error bar represents mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001.
