Extended Data Fig. 3: Long-term time-dependent analysis of cellular responses to the needle trauma.
From: Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
a–d, TP medium was injected into the striatum of Fischer 344 rats and rats were killed on days 4, 7 and 14 and 1, 3 and 6 months after surgery. The level of inflammatory cell infiltration into the needle track was determined by immunohistochemical staining with anti-IBA1 (a) and -MHCII (b) antibodies. c, The level of needle-trauma-induced neuroinflammation was determined by immunofluorescence staining with anti-IFNγ antibody. d, The level of cell death by needle trauma was analysed by TUNEL assay. (n = 5 per group). The mean value was connected by a red line. Each error bar represents mean ± s.e.m.
