Extended Data Fig. 1: Anti-inflammatory properties of parental F. prausnitzii DSM 32186 and oxygen tolerant DSM 32379.
From: Synergy and oxygen adaptation for development of next-generation probiotics
Modulation of IL-1β-induced IL-8 secretion by Caco-2 cells in contact with F. prausnitzii supernatants (strain A2-165 (DSM 17677) included as reference). Cells were exposed to bacterial supernatant with or without 4 ng/mL IL-1β for 6 hr. The horizontal axis group labels indicate dilution of filtered medium from the F. prausnitzii culture. p = 0.025 (DSM 32186 vs. A2-165, 1/25), p = 0.0000089 (LYBHI vs. A2-165, 1/25), p = 0.00013 (LYBHI vs. DSM32186, 1/25), p = 0.000016 (LYBHI vs. DSM32379, 1/25), p = 0.0000028 (LYBHI vs. A2-165, 1/10), p = 0.000013 (LYBHI vs. DSM32186, 1/10), p = 0.0000039 (LYBHI vs. DSM32379, 1/10). n = 3, ***p < 0.001, *p < 0.05 as determined by One-way ANOVA. The results were repeated in two independent experiments. Data are presented as mean ± s.e.m.
