Extended Data Fig. 4: Single-cell RNA-sequencing analysis confirms that Ndufs2 deletion is specific to distal lung epithelium in NDUFS2 cKO mice. | Nature

Extended Data Fig. 4: Single-cell RNA-sequencing analysis confirms that Ndufs2 deletion is specific to distal lung epithelium in NDUFS2 cKO mice.

From: Mitochondrial integrated stress response controls lung epithelial cell fate

Extended Data Fig. 4

a, Mki67 expression by genotype in each tissue type or in Sftpc lineage (tdTomato)-positive cells. Mki67+ cells were defined as cells with normalized UMI (unique molecular identifier) counts of Mki67 > 0 using sctransform. p values by Pearson’s chi-squared test. b, Heatmap showing expression of selected hallmark identifier genes for each clustered cell type. c, Relative contributions to each clustered cell type from NDUFS2 control and NDUFS2 cKO lungs. d–e, Expression of Ndufs2 gene in all clusters (d) and epithelial subclusters (e). Ndufs2 was deleted only in the distal lung epithelium.

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