Extended Data Fig. 6: Reactivity of TCR hybridomas against reported commensal epitopes.
From: Mapping the T cell repertoire to a complex gut bacterial community
a, The list of previously reported commensal epitopes tested in this experiment. Epitopes were pooled into sets of 6-7 for testing the ability to stimulate TCR hybridomas. b, Previously reported commensal epitopes were co-cultured with TCR hybridomas and dendritic cells. The SFB-specific 7B8 TCR transgenic T cells, a positive control, showed a response to Pool1, which includes the SFB antigen SFB3340. The 92 TCR hybridomas generated in this work were not responsive to any of the previously reported commensal epitopes.
