Extended Data Fig. 8: Comparing the performance of B1+2 and HRDetect.
From: Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers
a, ROC curves and PRCs comparing B1+2 and HRDetect performance on detecting HR deficiency (BRCA1d or BRCA2d) in an independent (HMF) test set. P value denotes comparison of AUROC by DeLong test. b,c, B1+2 feature importance for detecting HR deficiency in (b) an independent pan-cancer WGS dataset and (c) its non-BOPP subset . See Extended Data Fig. 1 and Methods for training and testing dataset summary. d, Scatter plot of B1+2 versus HRDetect scores across all 7,918 tumours, including those excluded from training and testing e, Scatter plot of scores from a random forest model trained only on SV features from the B1+2 (y axis) or HRdetect classifier (n = 7,918).
