Extended Data Fig. 4: nmrHAS2 mice showed a younger transcriptomic state.
From: Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
a. GSEA plots show that YOUNG gene set is upregulated, and OLD gene set is downregulated in all sequenced old nmrHAS2 mice of both sexes. * FDR<0.05, *** FDR<0.001. Exact FDR values are shown in Extended Data Fig. 4b–e. b. GSEA plots showing that OLD gene set is downregulated in WAT of old male nmrHAS2 mice. c. GSEA plots showing that that YOUNG gene set is upregulated, and OLD gene set is downregulated in the kidney of old male nmrHAS2 mice. d. GSEA plots showing that OLD gene set is downregulated in the muscle of old male nmrHAS2 mice. e. GSEA plots showing that that YOUNG gene set is upregulated, and OLD gene set is downregulated in the spleen of old male nmrHAS2 mice.
