Extended Data Fig. 6: Schematic of primary conclusions. | Nature

Extended Data Fig. 6: Schematic of primary conclusions.

From: LTP induction by structural rather than enzymatic functions of CaMKII

Extended Data Fig. 6: Schematic of primary conclusions.The alt text for this image may have been generated using AI.

Illustration of CaMKII enzymatic and structural functions and their roles in LTP induction. (1) CaMKII structural functions are required and sufficient to induce LTP. (2) CaMKII autophosphorylation at T286 is required to induce structural functions, but can be circumvented with ATP-competitive inhibitors that enhance GluN2B binding. (3) CaMKII phosphorylation of external substrates is not required to induce LTP.

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