Extended Data Fig. 6: Cryo-EM density maps of the TRPV3 tetramer and pentamer.

(a) and (b) Cryo-EM reconstructed maps of the TRPV3 tetramer (a) and pentamer (b), colored according to local resolution using a rainbow colour scale. (c) and (d) Representative cryo-EM densities of the tetramer (contour level at 5.5 RMSD) (c) and pentamer (contour level at 4.16 RMSD) (d), at 2.55Å and 4.38Å resolution, respectively (the TMDs in the pentamer map are of ~5.0-5.5 Å resolution, see local resolution color scheme in (b)).