Extended Data Fig. 9: Simulation of oligomeric state transitions. | Nature

Extended Data Fig. 9: Simulation of oligomeric state transitions.

From: A pentameric TRPV3 channel with a dilated pore

Extended Data Fig. 9: Simulation of oligomeric state transitions.The alt text for this image may have been generated using AI.

(a) Visualization of simulated traces. Each column represents an independent space that can be either empty (0) or occupied by a molecule with a specific oligomeric state (1, 2, 3, 4 or 5). Total space: 5250. Total time step: 2000. Initial setup (time step = 1): 5000 out of 5250 spaces had a value of 4 (tetramers) and 250 out of the 5250 spaces had a value of 0 (empty). (b) and (c) Close-up views of the simulated traces in (a) as indicated by the dashed boxes. 1: Empty → monomer → dimer → trimer → tetramer → pentamer transition. 2: Transitions between tetramer and pentamer states (with short pentamer dwell-times). 3: A long pentamer state event. 4: pentamer → tetramer → trimer → dimer → monomer → empty transition. (d) Time-evolution of oligomer counts. Top panel: Tetramers. Middle panel: Pentamers and lower oligomers (trimer, dimer, and monomer) aggregated. Bottom panel: Trimers, dimers and monomers. (e) Oligomer state dwell-times. Left to right: Lower oligomers (n = 34984), tetramer (n = 278141), and pentamer (n = 331579).

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