Extended Data Fig. 3: The TRPV3 tetramer and pentamer are reversible.

(a) to (f) Tetramer to pentamer transitions. (g) to (k) Pentamer to tetramer transitions. (l) Tetramer-pentamer-tetramer transition. (m) Pentamer-tetramer-pentamer-tetramer-pentamer-tetramer transition. White arrowheads indicate the occasionally observed monomers ‘attacking’ and inserting into tetramers to yield pentamers, and the observed monomers dissociating from pentamers to yield tetramers.