Extended Data Fig. 1: Outline of the design strategy for general-purpose DICs.
From: DNA-based programmable gate arrays for general-purpose DNA computing
a, Architecture for electronic chips integration. b, Hierarchical illustration of scalable DPGA integration (shown by the logical arrangement). We referred architectural properties of programmable electronic integrated circuits to design general-purpose DICs. In electronic integrated circuits, general-purpose chips can be physically integrated, with the information exchange between chips and storage realized via electrons. Analogous to electronic signal, DNA-UTS is used to transmit information. Inter-gate and inter-DPGA information transmission are all enabled by DNA-UTS. With uniform transmitted signals, integrability is permitted both at the gate and the DPGA levels. Asynchronous execution of cascaded DPGAs interdicts molecular diffusion between DPGAs, allowing DPGA integration. Hence, the scalability is enabled with the use of DNA-UTS and DNA origami register. In addition, arbitrary gate connection is allowed in a DPGA, providing rich programming space. In all, the programmability and the scalability support general-purpose computing with DICs.
