Extended Data Fig. 7: Activation of FcγRIIIa by individual plasma samples.
From: Neutralization, effector function and immune imprinting of Omicron variants
a Activation of high-affinity (V158) FcγRIIIa measured using Jurkat reporter cells and SARS-CoV-2 Wu-G614, BA.5, BQ.1.1 and XBB.1 S-expressing ExpiCHO as target cells. Luminescence (RLU) values from one experiment are shown with plasma samples from cohorts v-viii (n = 5 donors for cohort v, n = 5 for cohort vi, n = 6 for cohort vii and n = 5 for cohort viii) and compared to sotrovimab. Horizontal dotted line indicates the lowest limit of detectable activation (RLU = 115,737). b, AUC values from one experiment. Bars and values on top represent geometric mean AUC titers (GMT). Fold-change of activation with Omicron variants as compared to Wu-G614 is shown above each corresponding bar. Horizontal dashed line indicates the lowest limit of detectable activation (AUC = 150). n.a., not assayed.
