Fig. 5: Examples of non-annotated domain families with structural similarity to annotated domain families.
From: Clustering predicted structures at the scale of the known protein universe
a, Frag1-like domains. Three clusters were found enriched for the Frag1 Pfam annotation that had structural similarity to one cluster enriched for a domain of unknown significance (DUF998) and one cluster without annotations. b, Anthrax_toxA-like domains. A cluster enriched for the anthrax_toxA Pfam annotation was found with structural similarity to a cluster with no annotations. c, Two clusters without annotations were found with structural similarity to a cluster enriched for the gasdermin Pfam annotations. Cluster 2 gasdermin N-terminal domain structures reveal homology to human gasdermin E. The corresponding structural characteristics are highlighted. Some gasdermin domains were found fused to protease domains (UniProt: A0A2C5ZLK3). The bacterial gasdermin structure (PDB: 7N51) is similar to novel gasdermin domains from non-annotated cluster 2. The third cluster revealed homology to both animal and bacterial gasdermins.
