Extended Data Fig. 10: Pharmacological blockade of adrenergic receptors does not directly affect tumor cell proliferation.
From: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
a, Tumor expression of Ki67 relative to IgG determined by IHC in YUMMER tumors from mice under the indicated treatment conditions (IgG n = 14, atenolol n = 6, pooled from 4 independent experiments). Mann Whitney test. b, Tumor expression of Ki67 relative to IgG determined by IHC in YUMMER tumors from mice under the indicated treatment conditions (IgG n = 7, CGP 20712A n = 7, pooled from 2 independent experiments). Mann Whitney test. c, Tumor expression of Ki67 relative to IgG determined by IHC in PDAC tumors from mice under the indicated treatment conditions (IgG n = 8, propranolol n = 8, pooled from 2 independent experiments). Mann Whitney test. Unless otherwise specified, mean ± SEM is indicated in scatter plots. Two-sided statistical tests were used.
