Fig. 3: Allosteric interdomain and intradomain rotations are observed following ligand binding.
From: Sialoglycan binding triggers spike opening in a human coronavirus
a, Superposition of single HKU1-A spike protomers in the apo and ligand-bound closed holo state. The intrasubdomain axis of rotation in S1A is indicated as a dashed line; the disialoside is shown as spheres with carbon atoms in pink. b, Domain rotations associated with transition from the closed holo state to the holo up conformation (3-up state shown).
