Fig. 6: Proposed model for HKU1-A spike host cell engagement. | Nature

Fig. 6: Proposed model for HKU1-A spike host cell engagement.

From: Sialoglycan binding triggers spike opening in a human coronavirus

Fig. 6: Proposed model for HKU1-A spike host cell engagement.The alternative text for this image may have been generated using AI.

The HKU1-A spike engages a primary carbohydrate receptor, containing a 9-O-acetylated α2,8-linked disialoside, through the S1A domain. This causes the allosteric opening of the neighbouring S1B domain, which then binds to a putative secondary receptor. Created with BioRender.com.

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