Fig. 6: A model for CAN-3110 action as a function of HSV1 serology.
From: Clinical trial links oncolytic immunoactivation to survival in glioblastoma
In patients who are seropositive for HSV1, CAN-3110 elicits an initial augmented anti-HSV1 innate and T cell-mediated response (presumably by expansion and differentiation of memory into effector anti-HSV1 T cells) to clear the injected oHSV from tumours. This bystander T cell effect possibly mediates an effective antitumour effect by direct inflammation in the tumour and/or by stimulating ‘antigen spreading’ to also elicit T cell recognition of tumour antigens. In patients who are seronegative for HSV1, the absence of a rapid anti-HSV1 innate and T cell response leads to CAN-3110 replicative persistence with tumour growth overcoming viral-induced cytotoxicity and delayed immune activity against tumour antigens. The figure was generated using BioRender.com.
