Extended Data Fig. 1: Single injection of ketamine no longer causes antidepressant effects on day 3 or day 7.
From: Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
a, Schematic of LC-MS/MS (left) and experimental paradigm for behavioral tests (right) after i.p. injection of 10 mg kg−1 ketamine. b, Plasma concentration of ketamine after a single i.p injection of ketamine in CRS mice, as measured by LC-MS/MS. Dotted line indicates the half-life of ketamine. c, d, Behavioral effects at 3 d and 7 d after a single i.p. injection of ketamine in CRS mice in the FST (c) and the SPT (d). Sal: saline. Ket: ketamine. NS, not significant. Error bars indicate SEMs. (see Supplementary Table 1 for statistical analyses and n numbers). This figure is related to Fig. 1.
