Extended Data Fig. 1: Associations between CRPC myeloid cell density and NLR.
From: Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
a, Example images from the six-colour IF panel for identifying myeloid cells (example of staining of appendix) of CXCR2, CD15, CD11b, CD14, HLA-DR, and DAPI. Green pointer: CD11b+HLA-DRloCD15+CD14−, yellow arrow: CD11b+HLA-DRloCD15−CD14+. Scale bar = 20 µm. b,c, Scatter plot of peripheral blood NLR (d) and neutrophil count (x109/L) (e) versus log-transformed intratumor CD11b+HLA-DRloCD15−CD14+ cell density (cells/mm2) in cohort 1 (n = 48). d,e, Scatter plot of peripheral blood NLR (b) and neutrophil count (x109/L) (c) versus intratumor CD11b+HLA-DRloCD15+CD14− myeloid cell density (cells/mm2) in the validation cohort (n = 57). For a–e, correlation coefficients and p-values from the two-sided Spearman’s rank correlation analyses are shown. For d,e, estimated linear regression lines (pink) with 95% confidence interval (grey band). f, diagram of known CXCR1 and CXCR2 ligands. Source data are presented in the source data file.
