Extended Data Fig. 4: Immune cell densities in CRPC biopsies with CXCR2 inhibition.
From: Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
Intratumor immune cells densities (log-transformed density (cells/mm2)) in mCRPC biopsies taken during pre- (green) and on-treatment (blue), evaluating the immune cell subsets shown in all patients where on-target neutropenia (>30% mean decrease in neutrophils) was observed (n = 11 pairs). Data are represented by immune cell subset, individually, and as boxplots where the middle line is the median, the lower and upper hinges are the first and third quartiles, the upper whisker extends from the hinge to the largest value no further than 1.5 × interquartile range (IQR) from the hinge and the lower whisker extends from the hinge to the smallest value at most 1.5 × IQR from the hinge. Two-sided paired Wilcoxon signed-rank test p-values are shown.
