Extended Data Fig. 7: Quantification of HVV6 expression during the manufacturing of allogeneic CAR T cells from a donor with ciHHV-6 under different conditions.
From: Latent human herpesvirus 6 is reactivated in CAR T cells
(a) Schematic of experimental design. PBMCs from a ciHHV-6 donor were activated and subjected to four different conditions to assess the impact of individual steps of the CAR T cell manufacturing process. (b) Quantification of conditions in (a) over the 19 day culture process. HHV-6 copy number is shown and stable over the culture. (c) Per-gene HHV-6 viral RNA abundance at Day 1 and Day 19 of the full CAR T manufacturing process for the ciHHV-6 donor (left) and a donor previously analyzed with scRNA-seq (D98, right).
