Extended Data Fig. 4: Supporting analyses for HHV-6 expression during in vitro CAR T cell culture.
From: Latent human herpesvirus 6 is reactivated in CAR T cells
(a) Summary of observed (red) and permuted (gray) HHV-6B expression for four donors at day 19 in culture. The dotted line is at 10 UMIs, the threshold for a super-expressor. (b) Heatmap of HHV-6B expression for selected cells across 3 donors with detectable super-expressors. Columns are grouped based on HHV-6B gene programs (immediate early; early; late). (c) UMAP for 3 samples, noting marker genes and HHV-6B UMI expression (log transformed). The WPRE feature indicates the presence of the CAR transgene.
