Extended Data Fig. 2: Fascia-to-myofibroblast differentiation occurs within the En1-lineage.

a. UMAP representation of fibroblast showing GFP expression (EPFs) that were sorted and subclustered. b. UMAPs showing the skin fibroblast profile scores (top) and their associated EPF subclusters (bottom). c. UMAP of EPFs subclusters. d-e. An intermediate state with both naïve fascia and proinflammatory profiles supports the transition sprouting from fascia fibroblasts. d. Sample composition of EPF subclusters from the fascia-to-myofibroblast trajectory showing that the intermediate state appears in early wounds. e. Expression dot-plot of naïve fascia and proinflammatory markers being present in the intermediate state.