Extended Data Fig. 6: Mechanistic insights into 5′ Splice Site Recognition and Branch Helix Hinge Motions.
From: Structural insights into intron catalysis and dynamics during splicing
Comparison of the interactions surrounding the conserved 5′ splice site GU nucleotides for a. the group II RNP in the pre-1F state and b. the yeast spliceosome C complex (PDB:7B9V). The position of bpA adjacent nucleotides (C630 and U631 in a. and U68 and A69 in b.) are indicated with dashed lines and drawn as cartoon batons. c. Interaction network between J5/6 and J4/5. J5/6 RNA phosphate backbone conformations in d. the pre-1F and e. pre-2F states.
