Extended Data Fig. 4: Cryo-EM reconstructions from the PHF reactions.
From: Disease-specific tau filaments assemble via polymorphic intermediates
Projected slices, with an approximate thickness of 4.7 Å, orthogonal to the helical axis for the filaments formed in the PHF reactions. Filament names and resolutions are indicated in the top left; percentages of filament types in each cryo-EM data set are shown in the top right and the replicate and time point are indicated in the bottom left of each image. Circles around the slices are coloured as the structures of Fig. 4 in the main text.
