Extended Data Fig. 9: PHF crossover distances.
From: Disease-specific tau filaments assemble via polymorphic intermediates
a. Backbone traces, aligned at amino acids 339–354, for PHFs with crossover distances of 750 Å (red), 1000 Å (orange) and 3000 Å (yellow). Grey dotted lines and arrows indicate viewing planes and directions in subsequent panels. b. Side view of amino acids 305–320 and 365–380. c. The carbonyl of isoleucine 354 flips from PHFs with a crossover distance of 1000 Å, compared to those with a crossover distance of 3000 Å. d. The carbonyl of glutamic acid 342 flips from PHFs with a crossover distance of 750 Å, compared to those with a crossover distance of 1000 Å. e. Side view of backbone traces of amino acids 305–320 and 365–380 for PHFs with crossover distances of 3000 Å (top), 1000 Å (middle) and 750 Å (bottom). f. As in panel e, but for cartoon representations of two β-rungs.
