Extended Data Fig. 6: The TAF15 amyloid filament fold of FTLD-FET.
From: TAF15 amyloid filaments in frontotemporal lobar degeneration
a,b, Atomic model of TAF15 amyloid filaments from FTLD-FET shown for five differently-coloured TAF15 molecules perpendicular to (b) and along (c) the helical axis, showing that individual TAF15 molecules are not planar and that the N- and C-termini of neighbouring molecules interact with each other. c,d, Unmodelled densities (yellow), calculated by subtracting modelled density from the cryo-EM map, shown perpendicular to the helical axis (d) and rotated by 40° (e).
