Fig. 2: Cryo-EM characterization of amyloid filaments from individuals with FTLD–FET. | Nature

Fig. 2: Cryo-EM characterization of amyloid filaments from individuals with FTLD–FET.

From: TAF15 amyloid filaments in frontotemporal lobar degeneration

Fig. 2: Cryo-EM characterization of amyloid filaments from individuals with FTLD–FET.The alternative text for this image may have been generated using AI.

a, Representative cryo-EM micrograph of the sarkosyl-insoluble fraction of frontotemporal cortex grey matter from individual 1 with FTLD–FET. Abundant amyloid filaments are indicated by arrows. Scale bar, 50 nm. Results are representative of n ≥ 3 technical replicates per individual. Additional micrographs for all four individuals are shown in Extended Data Fig. 1b. b, Cryo-EM reconstructions of amyloid filaments from individuals 1–4 with FTLD–FET showing a readily traceable protein backbone and well-resolved amino acid side-chain densities. All four reconstructions have an identical filament fold. Resolution estimates are indicated. Scale bars, 2 nm.

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