Extended Data Fig. 4: Cryo-EM 2D class averages and 3D initial model of amyloid filaments from FTLD- FET. | Nature

Extended Data Fig. 4: Cryo-EM 2D class averages and 3D initial model of amyloid filaments from FTLD- FET.

From: TAF15 amyloid filaments in frontotemporal lobar degeneration

Extended Data Fig. 4: Cryo-EM 2D class averages and 3D initial model of amyloid filaments from FTLD- FET.The alternative text for this image may have been generated using AI.

a, The 50 most populated cryo-EM reference-free 2D class averages of amyloid filaments from FTLD- FET individual 1 are shown. Numbers indicate the percentage of filament segments in each class average with respect to the total number of classified segments. The displayed classes comprise ~80% of total filament segments. The circular mask has a diameter of 400 Å and corresponds to approximately one helical cross-over of the filaments. b,c, An initial 3D model of amyloid filaments from FTLD-FET individual 1, generated de novo from reference-free 2D class averages, viewed as a 2D projection along the helical axis (b) and as a central slice perpendicular to the helical axis (c). Scale bars, 2 nm.

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