Extended Data Fig. 7: Feature Importance for Biological Aging (FIBA) plots for all aging models in relation to cognition.
From: Organ aging signatures in the plasma proteome track health and disease
a, FIBA was applied to all aging models to assess peripheral versus central contributions to brain aging and cognitive decline (CDR-Global dementia rating). For each aging model, proteins were assessed for their contributions to the age gap association with cognition (CDR-Global, y-axis) and chronological age prediction accuracy (x-axis). Proteins for which permutation reduces the age gap association with cognition were termed FIBA+ , while proteins for which permutation strengthens the age gap association with dementia were termed FIBA-. FIBA+ proteins were used to train new cognition-optimized aging models from healthy individuals in the Knight-ADRC cohort. FIBA results for all aging models are shown in alphabetical order. (See ST15).
