Extended Data Fig. 10: Mapping CognitionOrganismal and CognitionArtery proteins to human organs and cell types.
From: Organ aging signatures in the plasma proteome track health and disease
a, The organ sources of highly weighted CognitionOrganismal proteins were investigated by analyzing their expression levels in the Gene Tissue Expression Atlas (GTEx) bulk RNA-seq database. Organ-level expression of pleiotrophin (PTN), transgelin (TAGLN), WNT1 inducible signalling pathway protein 2 (WISP2), and chordin like 1 (CHRDL1) are shown. Though not organ-specific, these genes were highly expressed in the arteries and brain. b, Single-cell RNA expression (Tabula Sapiens) of highly weighted CognitionOrganismal proteins in human vasculature. Mean normalized expression values and fraction of cells expressing the genes are shown. c, Single-cell RNA expression (Tabula Sapiens) of highly weighted CognitionArtery and StringDB-based “interacting” proteins in human vasculature. Mean normalized expression values and fraction of cells expressing the genes are shown.
